Search results
Found 29655 matches for
Researchers from the University of Oxford are using artificial intelligence to improve diagnostic accuracy for heart disease. The team hope to roll out the system across the NHS later this year, helping to improve patient outcomes and saving millions is misdiagnoses. The research, led by Prof Paul Leeson and RDM DPhil student Ross Upton (Cardiovascular Clinical Research Facility), took place in the Oxford University Hospitals Foundation Trust and is the basis of spin-out company Ultromics.
Protocol for a double-blind placebo-controlled randomised controlled trial assessing the impact of oral semaglutide in amyloid positivity (ISAP) in community dwelling UK adults.
INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), currently marketed for type 2 diabetes and obesity, may offer novel mechanisms to delay or prevent neurotoxicity associated with Alzheimer's disease (AD). The impact of semaglutide in amyloid positivity (ISAP) trial is investigating whether…
Glucocorticoid-induced hyperglycaemia in respiratory disease: a systematic review and meta-analysis.
The relative risk of glucocorticoid-induced hyperglycaemia is poorly quantified. We undertook a meta-analysis to estimate the association between glucocorticoid treatment and hyperglycaemia, overall and separately in individuals with and without diabetes and underlying respiratory disease. We search…
Repurposing Metformin as Therapy for Prostate Cancer within the STAMPEDE Trial Platform.
Metformin is a safe, well-tolerated, inexpensive treatment that can be given in addition to current standard-of-care therapies for prostate cancer. Its use might mitigate the deleterious side effects of castration and exert an additional anticancer effect. It will be incorporated in the STAMPEDE trial platform in s…
Statins and glycaemic control in individuals with diabetes: a systematic review and meta-analysis.
AIMS/HYPOTHESES: Current evidence indicates that statins increase the risk of incident diabetes; however, the relationship between statins and glycaemic control in people with established diabetes has not been well characterised. To address this question, we conducted a meta-analysis of randomised controll…
Recent findings on the effects of marine-derived n-3 polyunsaturated fatty acids on urinary albumin excretion and renal function.
Albuminuria (this includes microalbuminuria and macroalbuminuria) and reduced glomerular filtration rate are present not only in high-risk populations, but also in the general population. These manifestations of renal disease are associated with an increased risk of cardiovascular disease and may reflect subcli…
Obesity and target organ damage: diabetes.
Obesity is an important risk factor for the development of type 2 diabetes. The increasing incidence of obesity accounts in large part for the emergence of type 2 diabetes. Drug treatment of hyperglycaemia and hypertension lowers the risk of diabetic complications, but many of these treatments, including sul…
Risk factors for diabetic neuropathy and foot ulceration.
Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for interven…
Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaska Natives.
OBJECTIVE: To examine the association of seal oil and salmon consumption with impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) among Alaska Natives. RESEARCH DESIGN AND METHODS: Screening was performed on 666 Yup'ik Eskimos and Athabaskan Indians > or = 40 yea…
Gamma-glutamyl transferase and risk of type II diabetes: an updated systematic review and dose-response meta-analysis.
PURPOSE: We assessed the nature of the dose-response relationship between gamma-glutamyl transferase (GGT) levels and risk of incident type II diabetes mellitus (T2DM) in the general population. METHODS: Systematic review and dose-response meta-analysis of published prospective studies. Relevant studie…
Cross-sectional association between fish consumption and albuminuria: the European Prospective Investigation of Cancer-Norfolk Study.
BACKGROUND: Studies have shown a potential beneficial role for fish and fish oil consumption in the management of diabetes and its complications. The aim of this study is to examine the association between fish consumption and albuminuria in individuals with and without diabetes. STUDY DESIGN: A cross-secti…
Cardiovascular risk reduction in diabetes: underemphasised and overdue. Messages from major trials.
Diabetes markedly increases the risk of coronary artery disease and death, but is underrecognised as a cardiovascular risk factor, despite the existence of effective treatments. Because patients with diabetes are at high risk for coronary disease, they have more to gain from prevention. There is evidence from…
Implementing personalized medicine in diabetic kidney disease: Stakeholders' perspectives.
The promise of personalized medicine to deliver "the right treatments at the right time to the right person" is the next frontier in healthcare. However, to implement personalized medicine in chronic diseases such as diabetes mellitus and diabetic kidney disease (DKD), a number of different aspects need to be…
Association between alcohol consumption and diabetic retinopathy and visual acuity-the AdRem Study.
AIMS: We investigated the association between alcohol consumption and diabetic retinopathy and deterioration of visual acuity in individuals with Type 2 diabetes. METHODS: We conducted a cohort analysis of 1239 participants with Type 2 diabetes aged 55-81 years enrolled in the AdRem study, a sub-study o…