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Patel Group: Two tier protection and metabolic genotoxicity during blood production
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine
We study endogenous DNA damage caused by metabolites and their impact on the function of vertebrate stem cells and the ageing process
Chapman Group: Recombination mechanisms in immunity and cancer
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine
Mahmod group
Cardiovascular Clinical Research Facility Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
Our expertise is in clinical trials, whereby we aim to discover novel treatments for improving the health of patients with cardiac diseases. We use cardiovascular magnetic resonance imaging (CMR) and spectroscopy techniques to improve our understanding of myocardial metabolism and function, and for early detection of cardiac abnormalities in cardiomyopathy, heart failure, valve disease and diabetes. We use cardiopulmonary exercise test to understand cardiovascular exercise physiology, by studying how oxygen and other nutrients are used by the heart during exercise. We work closely with multidisciplinary research teams including MR physicists, biomedical engineers and other cardiac imaging experts in the UK and elsewhere in the world.
Sims Group: Computational Genomics
Nuffield Division of Clinical Laboratory Sciences
We are a computational biology research group using genomic and functional genomic data to study transcriptional regulation in neuroscience.
Lewandowski Group: Developmental Systems Physiology
Cardiovascular Clinical Research Facility Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
Our group focuses on understanding how alterations to early human development affect long-term disease risk and how to reduce risk through nutritional and lifestyle interventions. Disruptions to normal development, including exposure to pregnancy complications such as being born preterm, are risk factors for early heart failure, stroke and cardiovascular events. To study early developmental changes, we use multi-modality imaging, activity monitoring, questionnaire data and birth records, as well as blood sample collection to study cellular pathways in fetal through to young adult human cohorts.
Ray Group
We work on circadian rhythms, and nuclear receptors applied to both inflammation and energy metabolism. Our models range from cells to human populations.
Sauka-Spengler Group: Gene Regulatory Networks in Development and Disease
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We focus on systems level “big picture” approaches to understand gene regulation and build gene regulatory networks during development and disease in zebrafish, chick, lamprey and human models.
Jacobsen Group: Haematopoietic Stem Cell Biology
Research in the Jacobsen group is focused at unravelling normal and malignant hematopoietic stem and progenitor cell biology at the single cell level.
Townsend Group: Molecular Immunology
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
Jackson Group: Lymphatic Trafficking Research Group
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We focus on the mechanisms controlling the migration of leucocytes and tumour cells via lymph in health and disease.
Piechnik Group: Myocardial functional T1 mapping – Advanced cardiac magnetic resonance imaging techniques
We aim to further improve the clinical value of Cardiovascular Magnetic Resonance with application of advanced image analysis techniques.
de Bruijn Group: Developmental Haematopoiesis
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We study the embryonic origins of blood stem cells with the aim to inform the generation of these cells in culture, and ultimate produce clinically relevant blood stem cells for therapeutic purposes.
Higgs Group: Laboratory of Gene Regulation
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We use state-of-the-art laboratory and computational approaches to understand how mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases.
Davis Group: T-cell Biology
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We are interested in how lymphocytes decide to mount immune responses against, for example, tumours. This involves trying to understanding how leukocyte receptors, such as the T-cell receptor and immune checkpoints, are triggered.
Mead Group: Haematopoietic Stem Cell Biology
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
The Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. Our overarching aim is to improve the management of myeloproliferative neoplasms and related conditions through better monitoring and therapeutic targeting of malignant stem cell populations.
Neubauer Group: Oxford Centre for Clinical Magnetic Resonance Research
Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
OCMR uses sophisticated cardiac MR imaging and spectroscopy methods to phenotype cardiovascular disease – in small-scale proof-of-principle studies, large-scale multicentre clinical trials and ultra-large scale population imaging programmes. As well as running their own research programmes, OCMR serves as a collaboration partner to any group wanting to strengthen their clinical research with state of the art non-invasive phenotyping tools.
Vyas Group: Biology and Treatment of Human Myeloid Cancers
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We aim to understand the fundamental biological processes underlying normal and malignant haematopoiesis and translate this to improve patient outcomes through new rational therapies.
Redwood Group: Cardiac Contractility
Division of Cardiovascular Medicine
Defining important functional paradigms that lead to inherited cardiomyopathies, in search of novel treatments.
Kerr and Pezzella Group: Colorectal Clinical and Pathology Group
Nuffield Division of Clinical Laboratory Sciences
We lead colorectal cancer clinical trials, and study the basic biology of non-angiogenic and angiogenic tumours and mechanisms of vascular co-option.