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Kusumbe Lab | Tissue and Tumor Microenvironments
MRC Weatherall Institute of Molecular Medicine
We Study Vascular Changes Over Time With The Aim To Treat Diseases
Koohy Group: Machine Learning and Integrative Approaches in Immunology
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.
Toepfer Group: Cardiac Physiology and Disease Modeling
Understanding key mechanisms that govern cardiac muscle function in health and disease
Morrissey Group: Quantitative biology of cell fate and tissue dynamics
MRC Translational Immune Discovery Unit Nuffield Division of Clinical Laboratory Sciences
The group develops mathematical and statistical modelling approaches to study the dynamics and fate choices of stem cells within tissues.
Sahakyan Group: Integrative Computational Biology and Machine Learning
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Combining computational biology, computational chemistry, and machine learning techniques with biological big data to unravel the higher genomic code of life.
Wilkinson Group: Blood Stem Cell Expansion and Fitness
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine
Haematopoietic stem cells (HSCs) support blood cell production throughout life and are also used clinically in cell and gene therapies. We are studying the biology of this important stem cell population with the aim of developing new HSC-based therapies.
Simmons Group: Intestinal Immunity in Health and Disease
MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We define how the immune system functions in the intestine to promote health. We uncover the immune pathogenesis of intestinal diseases such as inflammatory bowel disease to develop better ways to treat these disorders.
Chakraverty Group: Haematopoietic Transplantation and Immunotherapy
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. While each of these approaches can be successful, they also fail in many patients as a result of tumour adaptations or diminished function of immune cells. Enhanced immunity can also lead to immune-related adverse events due to on- or off-target effects. We are exploring the mechanisms that underpin these failures and using this information to devise new strategies that can be translated into early phase clinical trials.
Psaila Group: The tumour microenvironment in blood cancers
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We focus on four key areas: (1) Dissecting how blood cancers create 'self-reinforcing' niches that promote clonal expansion and protect malignant clones from immunotherapies; (2) Development and application of human bone marrow organoids to study normal and malignant haematopoiesis and validate targets in a relevant tissue microenvironment; (3) Developing novel strategies to selectively target cancer stem cells and pathological megakaryocytes in myelofibrosis, a severe bone marrow malignancy; (4) Understanding our recent discovery that platelets contain a repertoire of DNA fragments sequestered from cell free DNA, and confirming clinical utility for cancer detection and for pre-natal diagnosis.
Davies Group: Genomics and Clinical Genome Editing
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We are primarily interested in understanding how the genome functions and to leverage this to develop novel genome editing based cellular therapies
Patel Group: Two tier protection and metabolic genotoxicity during blood production
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine
We study endogenous DNA damage caused by metabolites and their impact on the function of vertebrate stem cells and the ageing process
Chapman Group: Recombination mechanisms in immunity and cancer
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine
Mahmod group
Cardiovascular Clinical Research Facility Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
Our expertise is in clinical trials, whereby we aim to discover novel treatments for improving the health of patients with cardiac diseases. We use cardiovascular magnetic resonance imaging (CMR) and spectroscopy techniques to improve our understanding of myocardial metabolism and function, and for early detection of cardiac abnormalities in cardiomyopathy, heart failure, valve disease and diabetes. We use cardiopulmonary exercise test to understand cardiovascular exercise physiology, by studying how oxygen and other nutrients are used by the heart during exercise. We work closely with multidisciplinary research teams including MR physicists, biomedical engineers and other cardiac imaging experts in the UK and elsewhere in the world.
Sims Group: Computational Genomics
Nuffield Division of Clinical Laboratory Sciences
We are a computational biology research group using genomic and functional genomic data to study transcriptional regulation in neuroscience.
Lewandowski Group: Developmental Systems Physiology
Cardiovascular Clinical Research Facility Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
Our group focuses on understanding how alterations to early human development affect long-term disease risk and how to reduce risk through nutritional and lifestyle interventions. Disruptions to normal development, including exposure to pregnancy complications such as being born preterm, are risk factors for early heart failure, stroke and cardiovascular events. To study early developmental changes, we use multi-modality imaging, activity monitoring, questionnaire data and birth records, as well as blood sample collection to study cellular pathways in fetal through to young adult human cohorts.
Ray Group
We work on circadian rhythms, and nuclear receptors applied to both inflammation and energy metabolism. Our models range from cells to human populations.
Sauka-Spengler Group: Gene Regulatory Networks in Development and Disease
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We focus on systems level “big picture” approaches to understand gene regulation and build gene regulatory networks during development and disease in zebrafish, chick, lamprey and human models.
Jacobsen Group: Haematopoietic Stem Cell Biology
Research in the Jacobsen group is focused at unravelling normal and malignant hematopoietic stem and progenitor cell biology at the single cell level.
Townsend Group: Molecular Immunology
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine