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Research by Prof Andrew Wilkie and Prof Anne Goriely, published in PNAS, has identified the origins of some severe disease-causing mutations within the testicles of normal men. Particular mutations in the FGFR2 gene and a few other disease genes enable the mutated spermatogonia to produce not just sperm but extra copies of themselves, reproducing and spreading faster than the surrounding normal spermatogonia. This tumour-like growth means that over time, a greater proportion of sperm being produced carry disease-causing mutations, increasing the risk of fathering a child with a serious condition.
Neubauer Group: Oxford Centre for Clinical Magnetic Resonance Research
OCMR uses sophisticated cardiac MR imaging and spectroscopy methods to phenotype cardiovascular disease – in small-scale proof-of-principle studies, large-scale multicentre clinical trials and ultra-large scale population imaging programmes. As well as running their own research programmes, OCMR serves as a collaboration partner to any group wanting to strengthen their clinical research with state of the art non-invasive phenotyping tools.
How to find us
How to find the Diabetes Trials Unit
Publications
DTU Publications
Tyler Group: Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Using metabolic imaging to transform our approach to disease detection and treatment.
EVAREST (Echocardiography - Value and Accuracy at Rest and Stress)
EVAREST is CCRF-led multi-centre trial which aims to identify and validate novel blood and imaging biomarkers of potential value for consistent and accurate interpretation of stress echocardiography.
DPhil research opportunities
Find out about DPhil Research Opportunities available in 2020.