Search results
Found 30444 matches for
Congratulations to Dr Jame Felce, a postdoc with Simon Davis in the WIMM, who has been awarded a Sir Henry Wellcome Post-doctoral Fellowship.
Lapidaire Group: Brain Health Vascular Imaging
Division of Cardiovascular Medicine
Our group aims to make early diagnosis and continuous check-ups for (vascular) diseases accurate, affordable, and accessible for everyone. We focus on women’s vascular health and global health and aim to better understand the impact of hypertensive disorders of pregnancy on the brain.
Valkovič Group: Body MRS Group
Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
Pushing the Limits of Multi-nuclear Magnetic Resonance Spectroscopy of the Heart, Liver and Muscle
Zhang Group: Artificial Intelligence in Cardiovascular Imaging
Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
We work with clinicians and MR scientists on a day-to-day basis to develop novel AI machine-learning approaches for cardiovascular imaging.
Akbar Group: Extracellular Vesicles in Cardiovascular, Inflammatory and Metabolic Disease
Division of Cardiovascular Medicine
The Akbar Lab is interested in defining the therapeutic and diagnostic potential of extracellular vesicles for immunomodulation and precision medicine in cardiovascular, metabolic, and inflammatory diseases.
Goel Group: Cardiovascular genetics and bioinformatics
We have performed a number of genome-wide association analyses and meta-analyses on different case/control phenotypes and quantitative traits. After discovering genetic loci, our main interest is to refine the locus for causal variants using different computational approaches and integrating epigenetic data. We also have experience in rare variant data analysis from whole genome sequencing data.
Tyler Group
Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
Development and Application of Cardiac Magnetic Resonance Imaging and Spectroscopy
Pavlides Group: Quantitative MR and liver disease
Division of Cardiovascular Medicine
Our group investigates how MR techniques can be used to improve the care of patients with liver disease. The scope of our work is broad and ranges from evaluation of mature MR techniques in large multicentre studies, to proof-of-concept studies using new methods, or new clinical applications of existing technologies.
Holloway Group: Microfluidic Neurological Models (MNM)
Investigative Medicine Division
The Oxford MNM group focuses on developing in vitro models for neurological disease. Employing micro-fabrication techniques to define channels and features in cell culture devices at the scale of the cell and below, opens up the opportunity to shape cellular microenvironments to better reflect those found in the body. Our work uses these techniques and induced pluripotent stem cell (iPSC) technologies to create human cell culture models of the brain with the aim of enabling new possibilities to study neurovascular disease and improve drug discovery.
Cancer target identification and development
Nuffield Division of Clinical Laboratory Sciences
Our research interests lie in studying the molecular mechanisms of tumour growth and the target development. We focus on the impact of metabolism and epigenetic regulation on crosstalk between stromal cells and tumour cells in the tumour microenvironment. The ongoing investigated tumours include colorectal cancer, breast cancer and cholangiocarcinoma.
Hodson Group: Cellular Metabolism and GPCR Signalling
Oxford Centre for Diabetes, Endocrinology and Metabolism
We investigate how cellular metabolism and GPCR signaling converge to influence energy homeostasis in the periphery and brain during health and metabolic disease. We develop novel tools and technologies that allow us to study cell and tissue function with exquisite accuracy and detail, and apply these approaches to both preclinical models and human tissue.
Kusumbe Lab | Tissue and Tumor Microenvironments
MRC Weatherall Institute of Molecular Medicine
We Study Vascular Changes Over Time With The Aim To Treat Diseases
Koohy Group: Machine Learning and Integrative Approaches in Immunology
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.
Toepfer Group: Cardiac Physiology and Disease Modeling
Understanding key mechanisms that govern cardiac muscle function in health and disease
Morrissey Group: Quantitative biology of cell fate and tissue dynamics
MRC Translational Immune Discovery Unit Nuffield Division of Clinical Laboratory Sciences
The group develops mathematical and statistical modelling approaches to study the dynamics and fate choices of stem cells within tissues.
Sahakyan Group: Integrative Computational Biology and Machine Learning
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Combining computational biology, computational chemistry, and machine learning techniques with biological big data to unravel the higher genomic code of life.
Wilkinson Group: Blood Stem Cell Expansion and Fitness
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine
Haematopoietic stem cells (HSCs) support blood cell production throughout life and are also used clinically in cell and gene therapies. We are studying the biology of this important stem cell population with the aim of developing new HSC-based therapies.
Simmons Group: Intestinal Immunity in Health and Disease
MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We define how the immune system functions in the intestine to promote health. We uncover the immune pathogenesis of intestinal diseases such as inflammatory bowel disease to develop better ways to treat these disorders.
Chakraverty Group: Haematopoietic Transplantation and Immunotherapy
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. While each of these approaches can be successful, they also fail in many patients as a result of tumour adaptations or diminished function of immune cells. Enhanced immunity can also lead to immune-related adverse events due to on- or off-target effects. We are exploring the mechanisms that underpin these failures and using this information to devise new strategies that can be translated into early phase clinical trials.
Psaila Group: The tumour microenvironment in blood cancers
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We focus on four key areas: (1) Dissecting how blood cancers create 'self-reinforcing' niches that promote clonal expansion and protect malignant clones from immunotherapies; (2) Development and application of human bone marrow organoids to study normal and malignant haematopoiesis and validate targets in a relevant tissue microenvironment; (3) Developing novel strategies to selectively target cancer stem cells and pathological megakaryocytes in myelofibrosis, a severe bone marrow malignancy; (4) Understanding our recent discovery that platelets contain a repertoire of DNA fragments sequestered from cell free DNA, and confirming clinical utility for cancer detection and for pre-natal diagnosis.
Davies Group: Genomics and Clinical Genome Editing
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We are primarily interested in understanding how the genome functions and to leverage this to develop novel genome editing based cellular therapies