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Join Dr Matt Daniels and Prof Matthew Robson for a Pint of Science at St Aldates Tavern on 23 May from 6.30pm. All in the relaxed atmosphere of the pub, they’ll share the amazing technologies they use to better understand heart disease. From turning skin cells into heart cells, to using huge magnets to zoom in on the complexities of the body’s most powerful organ, don’t miss out this chance to learn more about research taking place in Oxford.
Royston Group - AI-based Analysis of the Bone Marrow; Integrating Spatial Transcriptomics & Multiplexed Imaging To Improve the Assessment of Blood Cancer (Funding Available)
The diagnosis of blood cancer requires integration of clinical, pathological, immunophenotypic and genetic / molecular findings. Accurate and consistent interpretation of bone marrow trephines (BMT) is particularly important for distinguishing between important blood cancer subtypes. Such distinction guides patient management and informs risk stratification. In response, our group have developed pioneering artificial intelligence (AI) approaches to accurately capture important tissue features of the bone marrow in blood cancer. This includes the development of automated and quantitative approaches to detect cellular and stromal changes present on routinely prepared diagnostic samples. We are now developing strategies to combine these approaches with newly developed advanced spatial transcriptomic and IHC / IF multiplexing strategies for patient-derived bone marrow biopsies.