Tyler Group - Development and Application of Novel Magnetic Resonance Imaging Approaches for the Assessment of Multi-System Disease (Funding available)
- Damian Tyler, Liz Tunnicliffe, Betty Raman
ABOUT THE RESEARCH
Magnetic Resonance Imaging (MRI) can provide numerous insights into the subclinical changes that precede serious diseases such as heart disease, neurodegenerative disease and diabetes. However, most imaging research focusses on a single organ system and fails to consider the cross-sectional relationships which occur across different organs (e.g. heart, liver, kidneys). MRI is perfectly suited to tissue characterisation in multiple organs and this project will investigate the development of novel MRI approaches to assess the potentially cumulative burden of multiple-organ dysfunction in different diseases with the aim to provide essential insight into multi-organ disease treatment and/or prevention. Based in the Oxford Centre for Clinical Magnetic Resonance Research (OCMR) at the John Radcliffe Hospital, this project will focus on the development and application of novel tissue characterisation approaches utilising the three state-of-the-art MRI systems housed in the unit, along with the expert knowledge of an internationally recognised MRI research group consisting of physicists, engineers, biomedical scientists and clinicians.
Funding is available for this project for fees at the home fee rate and a stipend of no less than £19.5K per year for three years.
Further information on how to apply, can be found on the RDM website.
The deadline for applications to this project is 12 noon (GMT) on Friday 28 April.
TRAINING OPPORTUNITIES
In addition to the wide range of training and skills development opportunities described below, the successful applicant will learn a wide array of medical imaging skills including novel applications development on 3T MRI systems, acquisition of MRI data on volunteers / patients and cutting-edge data analysis approaches.
Students are encouraged to attend the MRC Weatherall Institute of Molecular Medicine DPhil Course, which takes place in the autumn of their first year. Running over several days, this course helps students to develop basic research and presentation skills, as well as introducing them to a wide range of scientific techniques and principles, ensuring that students have the opportunity to build a broad-based understanding of differing research methodologies.
Generic skills training is offered through the Medical Sciences Division's Skills Training Programme. This programme offers a comprehensive range of courses covering many important areas of researcher development: knowledge and intellectual abilities, personal effectiveness, research governance and organisation, and engagement, influence, and impact. Students are actively encouraged to take advantage of the training opportunities available to them.
As well as the specific training detailed above, students will have access to a wide range of seminars and training opportunities through the many research institutes and centres based in Oxford.
The Department has a successful mentoring scheme, open to graduate students, which provides an additional possible channel for personal and professional development outside the regular supervisory framework. We hold an Athena SWAN Silver Award in recognition of our efforts to build a happy and rewarding environment where all staff and students are supported to achieve their full potential.
PUBLICATIONS
|
1 |
Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants. McCracken C, Raisi-Estabragh Z, Veldsman M, Raman B, Dennis A, Husain M, Nichols TE, Petersen SE, Neubauer S.Nat Commun. 2022 Dec 21;13(1):7839. doi: 10.1038/s41467-022-35321-2.PMID: 36543768 |
|
2 |
Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. Raman B, Cassar MP, Tunnicliffe EM, Filippini N, Griffanti L, Alfaro-Almagro F, Okell T, Sheerin F, Xie C, Mahmod M, Mózes FE, Lewandowski AJ, Ohuma EO, Holdsworth D, Lamlum H, Woodman MJ, Krasopoulos C, Mills R, McConnell FAK, Wang C, Arthofer C, Lange FJ, Andersson J, Jenkinson M, Antoniades C, Channon KM, Shanmuganathan M, Ferreira VM, Piechnik SK, Klenerman P, Brightling C, Talbot NP, Petousi N, Rahman NM, Ho LP, Saunders K, Geddes JR, Harrison PJ, Pattinson K, Rowland MJ, Angus BJ, Gleeson F, Pavlides M, Koychev I, Miller KL, Mackay C, Jezzard P, Smith SM, Neubauer S.EClinicalMedicine. 2021 Jan 7;31:100683. doi: 10.1016/j.eclinm.2020.100683. eCollection 2021 Jan. PMID: 33490928 |
|
3 |
Association Between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights From a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach. Raman B, Tunnicliffe EM, Chan K, Ariga R, Hundertmark M, Ohuma EO, Sivalokanathan S, Tan YJG, Mahmod M, Hess AT, Karamitsos TD, Selvanayagam J, Jerosch-Herold M, Watkins H, Neubauer S.Circulation. 2021 Nov 16;144(20):1656-1658. doi: 10.1161/CIRCULATIONAHA.121.054015. Epub 2021 Nov 15. PMID: 34780254 |
|
4 |
Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease.Banerjee R, Pavlides M, Tunnicliffe EM, Piechnik SK, Sarania N, Philips R, Collier JD, Booth JC, Schneider JE, Wang LM, Delaney DW, Fleming KA, Robson MD, Barnes E, Neubauer S.J Hepatol. 2014 Jan;60(1):69-77. doi: 10.1016/j.jhep.2013.09.002. Epub 2013 Sep 12. PMID: 24036007 |