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RDM have introduced a mentoring scheme for all members of staff. The aim of the scheme is to assist all staff to achieve personal and professional growth through a mentoring relationship that provides support as they progress and develop within the University.
Self-Assembled Peptide-Based Fibrous Hydrogel as a Biological Catalytic Scaffold for Nitric Oxide Generation and Encapsulation.
Biomolecular hydrogels are promising scaffolds for biomedical applications ranging from controlled drug release to personalized medicine. However, existing macromolecular scaffolds for nitric oxide (NO) release face several challenges, such as a low payload capacity, rapid release, and limited biocompatibility.…
Rapidly self-healing electronic skin for machine learning-assisted physiological and movement evaluation.
Emerging electronic skins (E-Skins) offer continuous, real-time electrophysiological monitoring. However, daily mechanical scratches compromise their functionality, underscoring urgent need for self-healing E-Skins resistant to mechanical damage. Current materials have slow recovery times, impeding reli…
New options and techniques in reconstructing the sacrum.
PURPOSE: Sacral tumours, both benign and malignant, often necessitate surgical removal (sacrectomy) to achieve optimal outcomes. However, this procedure disrupts the pelvic ring's stability, potentially leading to pain and limited mobility. METHODS: This article explores innovative approaches to recon…
Synthesis and characterization of amine-functionalized graphene as a nitric oxide-generating coating for vascular stents.
Drug-eluting stents are commonly utilized for the treatment of coronary artery disease, where they maintain vessel patency and prevent restenosis. However, problems with prolonged vascular healing, late thrombosis, and neoatherosclerosis persist; these could potentially be addressed via the local gen…
The emergence of Fanconi anaemia type S: a phenotypic spectrum of biallelic BRCA1 mutations.
BRCA1 is involved in the Fanconi anaemia (FA) pathway, which coordinates repair of DNA interstrand cross-links. FA is a rare genetic disorder characterised by bone marrow failure, cancer predisposition and congenital abnormalities, caused by biallelic mutations affecting proteins in the FA pathway. Germline m…
Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.
Children with Down syndrome (DS) have a high risk of GATA1-associated myeloid leukemia (ML-DS) before age 4. Somatic N-terminal GATA1 mutations (GATA1s) are necessary, but not sufficient, for ML-DS, but their significance at birth for individual babies and whether mutations occur after birth is unclear.…
Models of Cerebrovascular Reactivity in BOLD-fMRI and Transcranial Doppler Ultrasound.
The ability of cerebrovasculature to respond to meet tissue demands is vital for normal brain function and health. Cerebrovascular reactivity (CVR), a measure of the responsiveness of cerebrovasculature to vasoactive stimuli, is a valuable tool for evaluating cerebrovascular health. While CVR is commonly…
Strategies for anticoagulation in patients with thrombocytopenia and cancer-associated thrombosis (START): design and rationale of the START pilot randomized controlled trial
Patients with cancer have high risks of venous thromboembolism (VTE) as well as thrombocytopenia. Thrombocytopenia is associated with an increased risk of bleeding. Hence, treatment of acute VTE with anticoagulation is challenging in patients with cancer and thrombocytopenia. Data are limited in the mana…
Immune-epithelial-stromal networks define the cellular ecosystem of the small intestine in celiac disease.
The immune-epithelial-stromal interactions underpinning intestinal damage in celiac disease (CD) are incompletely understood. To address this, we performed single-cell transcriptomics (RNA sequencing; 86,442 immune, parenchymal and epithelial cells; 35 participants) and spatial transcriptomics (20 p…
Glucokinase activity in diabetes: too much of a good thing?
Type 2 diabetes (T2D) is a global health problem characterised by chronic hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised to stimulate insulin release it was initially argued that drugs that stimulate glucokinase (the first enzyme in glucose metabolism) would enhanc…
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.
Chronic hyperglycaemia causes a dramatic decrease in mitochondrial metabolism and insulin content in pancreatic β-cells. This underlies the progressive decline in β-cell function in diabetes. However, the molecular mechanisms by which hyperglycaemia produces these effects remain unresolved. Using isolat…
Co-design of a Mobile Stroke Unit pathway highlights uncertainties and trade-offs for viable system-wide implementation in the English and Welsh NHS.
BACKGROUND: Mobile stroke units (MSUs) are specialist ambulances equipped with scanning and point of care testing that can identify patients eligible for intravenous thrombolysis - medication to dissolve a clot used in ischaemic strokes - and provide this on location. While benefits of MSUs have been demonst…
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells.
Iron is an irreplaceable co-factor for metabolism. Iron deficiency affects >1 billion people and decreased iron availability impairs immunity. Nevertheless, how iron deprivation impacts immune cell function remains poorly characterised. We interrogate how physiologically low iron availability affects CD8+ T cell met…
Outcome measures for randomised clinical trials and multicentre observational studies of cardiovascular diseases published in major clinical journals: systematic review and evidence mapping.
BACKGROUND: Outcome measure choice and definition can determine the result of the study. We describe outcome measures and their definitions for cardiovascular studies in highly cited medical journals. METHODS: Cardiovascular phase III or IV randomised clinical trials (RCTs) or multicentre observation…