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Dr Rupert McShane has just published results from a study he led looking at the use of ketamine intravenous infusions in people with treatment-resistant depression The study, published in the Journal of Psychopharmacology, confirmed that ketamine has a rapid antidepressant effect in some patients with severe depression who have not responded to other treatments.
Davies Group: Genomics and Genome Editing
My lab is interested in understanding how the genome functions and leveraging this to develop genome editing strategies to treat human disease.
Mead Group: Gene-Environment Initiated Disease Progression in Myeloproliferative Neoplasms
The overarching aim of my research group is to improve the diagnosis, risk-stratification and treatment of myeloproliferative neoplasms (MPN), fuelled by a better understanding of the pathobiology of this largely incurable form of blood cancer. Using a combination of single-cell genomics, stem cell assays and in…
Piechnik Group: Experimental and clinical translation of advanced quantitative cardiovascular magnetic resonance imaging techniques.
The Advanced Cardiovascular Image Analysis group works together with OCMR core lab analysts and clinicians at the frontline CMR clinical facility.
Chakraverty Group: Identifying novel CD4+ T cell platforms for immunotherapy
This project brings together laboratories with established international reputations in T cell immunotherapy (Prof. Chakraverty) and the biology and treatment of acute myeloid leukaemia (AML, Prof. Vyas). The overall aim of the project is to determine how a sub-population of CD4+ T cells develop cytotoxic functio…
Kassouf Group: Understanding the principles of gene regulation in health and disease.
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. We use the most recent genomics technologies and computational approaches to study both the entire genome and individual genes in detail. We study all aspects…
Sharma Group: Comparative Analysis of TCR-Mediated Cytotoxicity Using Genome-Wide CRISPR Screens to Identify Host Factors in Natural vs. Vaccine-Induced Immunity
This PhD project aims to systematically identify cellular factors that regulate T cell cytotoxicity by comparing matched TCR clones derived from natural viral infections versus vaccination responses, using genome-wide CRISPR knockout screens that the Sharma group specializes in, conducted in both target cells…
Choudhury Group: Immuno-modulation and inflammation reprogramming in cardio-metabolic disease
The laboratory focuses on how environmental factors influence bone marrow function—specifically, how stimuli such as exosomal protein and microRNA delivery and metabolic reprogramming of epigenetic marks shape hematopoietic responses.
Nerlov Group: Single Cell Biology and Machine Learning in Blood Development, Cancer and Ageing
The Nerlov laboratory studies the fundamental processes by which blood (or hematopoietic) stem cells sustain blood cell production throughout life and how ageing and haematological malignancies perturb this process, in order to develop molecularly informed strategies to counteract adverse blood phenotypes.
Simmons Group: Engineering Intestinal Mesenchymal Niches to Promote Epithelial Barrier Health Through Life
The main focus of our lab is in understanding intestinal barrier immunity in health and disease. We are interested in how the epithelial, mesenchymal and immune cells of the intestine intersect through life to maintain a healthy dialogue with commensal microflora while protecting against enteric pathogens, pr…
Zhang Group: Artificial Intelligence for cardiovascular imaging and clinical big data
The Group’s primary aim is to advance cardiac diagnostic imaging and enrich cardiovascular clinical studies through the deep integration of AI machine learning with cardiovascular medicine, imaging and cardiac big data. Students will explore various opportunities addressing unmet clinical needs in cardiac i…
Valkovic Group: Non-invasive cardiac metabolism assessment using ultra-high field (7T) MR Spectroscopy and supported by AI
My group at the Oxford Centre for Clinical Magnetic Resonance Research (OCMR) is focused on development of new methods for cardiac metabolism assessment using magnetic resonance spectroscopy (MRS). This project will utilize the increased signal-to-noise ratio of the ultrahigh field (7T) system, as w…
Watkins Group: Genetic therapies for Inherited Heart Muscle Disease
The Watkins group uses molecular genetic analysis of heart disease to define disease mechanisms and create genetic therapies.