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Translational Dermatology Unit
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. We have a particular focus on T cells which recognise inflammatory lipids presented by CD1a. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Drakesmith Group: Iron and Immunity
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We are investigating how iron and anaemia influence immunity and infectious diseases. Our research inspires treatments that control iron physiology to benefit the host at the expense of pathogens.
Murphy, Roberts and Stanworth Group: Oxford Clinical Research in Transfusion Medicine
Nuffield Division of Clinical Laboratory Sciences
Increasing and disseminating the evidence-base to improve practice in Transfusion Medicine.
Goriely Group: Clinical genetics
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We are using a human genetic approach that relies on the latest developments of Next Generation Sequencing technology to study the intimate relationship that exists between the occurrence of new mutations and the regulation of cell fate choices in the male germline. Because life-long production of sperm is supported by regular divisions of so-called spermatogonial stem cells, each one of us acquire ~30-100 new mutations in our genome, the majority of which is paternal in origin.
Li Group: Immunobiology and Immunotherapy
Nuffield Division of Clinical Laboratory Sciences
Understanding immune recognition and developing cancer immunotherapy.
Boultwood Group: Blood Cancer UK Molecular Haematology Unit
Nuffield Division of Clinical Laboratory Sciences
We study the molecular mechanisms involved in disease initiation and progression in the myelodysplastic syndromes (MDS) in order to better understand disease pathogenesis and to identify new therapeutic targets and prognostic markers for this disorder.
Milne Group: Epigenetic Control of Gene Expression in Leukaemia and Haematopoiesis
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Aberrant epigenetic changes are a driving force in many human cancers. The focus of our lab is centred on understanding how epigenetics impacts gene regulation so that this information can potentially be used to develop new therapeutic strategies.
Gibbons Group: ATRX Group
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We are interested in the function of the chromatin remodelling factor ATRX and how mutations in this factor lead to human disease.
Nerlov Group: Hematopoietic Stem Cell Genetics
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Hematopoietic stem cell (HSC) transplantation is the only stem cell therapy in routine clinical use, and it is also the cell type that gives rise to most blood cancers. We use single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
Wilkie Group: Clinical Genetics
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
The ability to sequence whole exomes and genomes of individual people has revolutionised our ability to explore the full spectrum of genetic mutations causing serious human diseases. Working closely with the craniofacial teams based in Oxford and other UK units, we specialise in the application of these methods to children born with a serious malformation of the skull termed craniosynostosis.
Rahimi Group: Healthcare Innovation and Evaluation
Division of Cardiovascular Medicine
Our research is devoted to advancing the science of healthcare delivery for management of major cardiovascular conditions and harnessing the power of Big Data to drive change. Large healthcare datasets are being used to create more transparency about healthcare performance and for better risk stratification of populations for more targeted interventions.
Antoniades Group: The Oxford Translational Cardiovascular Research Group
Division of Cardiovascular Medicine
Our group studies the interplay between adipose tissue and the cardiovascular system. Using translational approaches, we develop novel diagnostic tools for the early detection of cardiovascular diseases and risk stratification. We also work towards the discovery of new therapeutic targets for the prevention and treatment of cardiovascular diseases, in the context of obesity and diabetes.