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Rider Group: Obesity, Heart Failure, Linking Myocardial Metabolism and Function
Division of Cardiovascular Medicine Oxford Centre for Clinical Magnetic Resonance Research
We use multi-parametric cardiac magnetic resonance imaging and multinuclear magnetic resonance spectroscopy to non-invasively investigate the relationship between cardiac metabolism and cardiac function.
Reilly Group: Molecular signalling in adverse myocardial remodelling and fibrosis
Division of Cardiovascular Medicine
Our group aims to understand the microRNA-mediated mechanisms fundamental to cardiac fibrosis and electrical remodelling that are associated with atrial fibrillation (a very common rhythm disorder). We are particularly interested in functional cross-talk between two major cell types in the heart – myocytes and fibroblasts.
Tzima Group: Mechanotransduction Group
Division of Cardiovascular Medicine
Vascular Mechanotransduction in health and disease.
Ramracheya Group: Pancreatic Islet and Gut Hormones in Health, Diabetes and Metabolic Surgery
Oxford Centre for Diabetes, Endocrinology and Metabolism
Our goal is to dissect the molecular mechanisms by which gut hormones, namely GLP-1 and PYY, improve glucose-mediated insulin and glucagon secretion in pancreatic islets. Dysfunction of both secretory processes contributes to the onset of type 2 diabetes and represents the target of effective diabetes intervention.
Rorsman Group
Oxford Centre for Diabetes, Endocrinology and Metabolism
We study cellular physiology of pancreatic islets – the small organs that regulate the whole-body sugar levels. Our work will help to find new treatments for diabetes – a disease that is characterised by uncontrolled blood sugar.
Thakker Group: Academic Endocrine Unit
Oxford Centre for Diabetes, Endocrinology and Metabolism
We investigate the genetic, molecular and physiological basis of endocrine disorders that affect calcium homeostasis, and endocrine tumour development. By identifying and understanding the underlying mechanisms, we aim to establish better diagnostic methods and develop novel targeted therapies for these disorders to improve patient care.
Karpe, Hodson and Christodoulides Group: Metabolic Research Group
Oxford Centre for Diabetes, Endocrinology and Metabolism
We apply an integrated approach to human metabolic disease which involves genetic, genomic, cell biology and whole body metabolic studies to understand the pathogenesis of the complications of obesity such as fatty liver disease, type 2 diabetes and cardiovascular disease.
Tomlinson Group: Metabolism and Steroid Hormone Biology
Oxford Centre for Diabetes, Endocrinology and Metabolism
We work to understand how hormones regulate metabolic health in liver, fat and skeletal muscle. Our research has helped to define the role of ‘pre-receptor’ hormone metabolism in the pathogenesis of metabolic disease and has contributed to the development of novel interventions with the ultimate aim of improving patient care.
Buchan Group: Responsible Research and Innovation
Investigative Medicine Division
We are focusing on how to make research and innovation relevant to society, sustainable and fair for everyone.
Rehwinkel Group: Nucleic Acid Sensing
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
Translational Dermatology Unit
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. We have a particular focus on T cells which recognise inflammatory lipids presented by CD1a. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Drakesmith Group: Iron and Immunity
Investigative Medicine Division MRC Translational Immune Discovery Unit MRC Weatherall Institute of Molecular Medicine
We are investigating how iron and anaemia influence immunity and infectious diseases. Our research inspires treatments that control iron physiology to benefit the host at the expense of pathogens.
Murphy, Roberts and Stanworth Group: Oxford Clinical Research in Transfusion Medicine
Nuffield Division of Clinical Laboratory Sciences
Increasing and disseminating the evidence-base to improve practice in Transfusion Medicine.
Goriely Group: Clinical genetics
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We are using a human genetic approach that relies on the latest developments of Next Generation Sequencing technology to study the intimate relationship that exists between the occurrence of new mutations and the regulation of cell fate choices in the male germline. Because life-long production of sperm is supported by regular divisions of so-called spermatogonial stem cells, each one of us acquire ~30-100 new mutations in our genome, the majority of which is paternal in origin.
Li Group: Immunobiology and Immunotherapy
Nuffield Division of Clinical Laboratory Sciences
Understanding immune recognition and developing cancer immunotherapy.
Boultwood Group: Blood Cancer UK Molecular Haematology Unit
Nuffield Division of Clinical Laboratory Sciences
We study the molecular mechanisms involved in disease initiation and progression in the myelodysplastic syndromes (MDS) in order to better understand disease pathogenesis and to identify new therapeutic targets and prognostic markers for this disorder.
Milne Group: Epigenetic Control of Gene Expression in Leukaemia and Haematopoiesis
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Aberrant epigenetic changes are a driving force in many human cancers. The focus of our lab is centred on understanding how epigenetics impacts gene regulation so that this information can potentially be used to develop new therapeutic strategies.
Gibbons Group: ATRX Group
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
We are interested in the function of the chromatin remodelling factor ATRX and how mutations in this factor lead to human disease.
Nerlov Group: Hematopoietic Stem Cell Genetics
MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
Hematopoietic stem cell (HSC) transplantation is the only stem cell therapy in routine clinical use, and it is also the cell type that gives rise to most blood cancers. We use single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
Wilkie Group: Clinical Genetics
MRC Weatherall Institute of Molecular Medicine Nuffield Division of Clinical Laboratory Sciences
The ability to sequence whole exomes and genomes of individual people has revolutionised our ability to explore the full spectrum of genetic mutations causing serious human diseases. Working closely with the craniofacial teams based in Oxford and other UK units, we specialise in the application of these methods to children born with a serious malformation of the skull termed craniosynostosis.