Radcliffe Department of Medicine

Kusumbe Lab | Tissue and Tumor Microenvironments

We Study Vascular Changes Over Time With The Aim To Treat Diseases

Koohy Group: Machine Learning and Integrative Approaches in Immunology

We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.

Morrissey Group: Quantitative biology of cell fate and tissue dynamics

The group develops mathematical and statistical modelling approaches to study the dynamics and fate choices of stem cells within tissues.

Simmons Group: Intestinal Immunity in Health and Disease

We define how the immune system functions in the intestine to promote health. We uncover the immune pathogenesis of intestinal diseases such as inflammatory bowel disease to develop better ways to treat these disorders.

Townsend Group: Molecular Immunology

Jackson Group: Lymphatic Trafficking Research Group

We focus on the mechanisms controlling the migration of leucocytes and tumour cells via lymph in health and disease.

Davis Group: T-cell Biology

We are interested in how lymphocytes decide to mount immune responses against, for example, tumours. This involves trying to understanding how leukocyte receptors, such as the T-cell receptor and immune checkpoints, are triggered.

Dong Group: Human T cell responses against Viruses & Cancer

Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.

Eggeling Group

We apply and optimize advanced optical microscopy techniques, such as super-resolution STED microscopy, to decipher molecular dynamics in an unprecedented way. Our main focus is molecular plasma membrane organization, especially following immune responses.

Rehwinkel Group: Nucleic Acid Sensing

Translational Dermatology Unit

The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. We have a particular focus on T cells which recognise inflammatory lipids presented by CD1a. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.

Drakesmith Group: Iron and Immunity

We are investigating how iron and anaemia influence immunity and infectious diseases. Our research inspires treatments that control iron physiology to benefit the host at the expense of pathogens.

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