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BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

Original publication

DOI

10.1161/STROKEAHA.108.525386

Type

Journal article

Journal

Stroke

Publication Date

03/2009

Volume

40

Pages

e50 - e52

Keywords

Animals, Bias, Conflict of Interest, Disease Models, Animal, Drug Industry, Humans, Random Allocation, Research Design, Research Support as Topic, Sample Size, Stroke, Treatment Outcome