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We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.

Original publication

DOI

10.1038/340443a0

Type

Journal article

Journal

Nature

Publication Date

10/08/1989

Volume

340

Pages

443 - 448

Keywords

Animals, Cell Line, Cell Membrane, Cell Transformation, Viral, Histocompatibility Antigens Class I, Macromolecular Substances, Mutation, Nucleoproteins, Orthomyxoviridae, Protein Conformation, RNA-Binding Proteins, Viral Core Proteins, Viral Proteins, beta 2-Microglobulin