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Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacterial cdNs, modulating innate signaling in a manner independent of STING to promote an antibacterial state.

Original publication

DOI

10.1016/j.immuni.2017.03.005

Type

Journal article

Journal

Immunity

Publication Date

21/03/2017

Volume

46

Pages

337 - 339