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Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors display a more selective tissue distribution. Here we characterize an inhibitory receptor, termed ILT4, which is selectively expressed in monocytes, macrophages, and dendritic cells (DCs), binds classical class I molecules and the nonclassical class I molecules HLA-G, and transduces negative signals that can inhibit early signaling events triggered by stimulatory receptors. ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity.

Type

Journal article

Journal

J Immunol

Publication Date

01/04/1998

Volume

160

Pages

3096 - 3100

Keywords

Animals, B-Lymphocytes, Cell Line, Cells, Cultured, Dendritic Cells, HLA Antigens, Histocompatibility Antigens Class I, Humans, Intracellular Signaling Peptides and Proteins, Killer Cells, Natural, Lymphocyte Activation, Macrophage Activation, Macrophages, Mast Cells, Membrane Glycoproteins, Mice, Molecular Weight, Monocytes, Protein Binding, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Protein Tyrosine Phosphatases, Rats, Rats, Wistar, Receptors, Immunologic, Serotonin, Serotonin Antagonists, Signal Transduction