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Activation of potassium channels normally serves to reduce cellular activity but recent data indicate that the glucagon-secreting alpha cells are different in this respect and that inhibition of voltage-gated potassium channels results in a paradoxical inhibition of glucagon secretion. Here we discuss these findings and attempt to provide a model for the regulation of glucagon secretion that incorporates these observations.

Original publication

DOI

10.1007/s00125-010-1823-8

Type

Journal article

Journal

Diabetologia

Publication Date

09/2010

Volume

53

Pages

1827 - 1830

Keywords

Animals, Electrophysiology, Glucagon, Glucagon-Secreting Cells, Humans, Islets of Langerhans, Models, Biological, Potassium Channels, Voltage-Gated