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Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Original publication

DOI

10.1038/ncomms9658

Type

Journal article

Journal

Nat Commun

Publication Date

04/12/2015

Volume

6

Keywords

Adult, Aged, Aged, 80 and over, European Continental Ancestry Group, Female, Forced Expiratory Volume, Genome-Wide Association Study, Humans, Lung, Lung Diseases, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult