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We have cloned c-Irx2, a chick homologue of the Xiro2 and mIrx2 genes and a new member of the Iroquois family of homeodomain-containing transcription factors. Strikingly, c-Irx2 expression reveals an early subdivision of the neural plate at late primitive streak stages which later transiently resolves to a single stripe within the developing hindbrain corresponding to rhombomere 1.


Journal article


Mech Dev

Publication Date





203 - 206


Amino Acid Sequence, Animals, Cerebellum, Chick Embryo, DNA, Complementary, Gene Expression, Homeodomain Proteins, Mesencephalon, Molecular Sequence Data, Rhombencephalon, Sequence Homology, Amino Acid, Time Factors, Transcription Factors