Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

There are few studies that have examined the frequencies of epitope-specific CD4(+) T cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. In this study we tracked human epitope-specific CD4(+) T cell responses over time after immunisation with a live attenuated varicella zoster virus vaccine by MHC Class II tetrameric complexes and functional assays. We show that the peptide-specific responses reflect those against whole virus antigens, and are similar in both frequency and phenotype to those found in healthy volunteers, despite a highly attenuated and clinically inapparent infection.

Original publication

DOI

10.1016/j.vaccine.2009.08.081

Type

Journal article

Journal

Vaccine

Publication Date

09/12/2009

Volume

27

Pages

7398 - 7401

Keywords

Adult, Antibodies, Viral, Antigens, Viral, CD4-Positive T-Lymphocytes, Chickenpox, Chickenpox Vaccine, Epitopes, T-Lymphocyte, Female, HLA-DR Antigens, HLA-DRB1 Chains, Health Personnel, Humans, Immunity, Cellular, Immunoglobulin G, Interferon-gamma, Leukocytes, Mononuclear, Male, Middle Aged, Vaccines, Attenuated, Young Adult