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A study of rheological determinants (plasma viscosity, whole-blood viscosity, and erythrocyte deformability) was made in 24 matched pairs of patients with homozygous sickle cell disease, with and without homozygous alpha-thalassaemia 2. Patients with coexisting alpha-thalassaemia showed a significant increase in erythrocyte deformability measured as filtration of washed erythrocytes through 5 micron diameter pores and also as viscosity of whole blood at high shear rate (230s-1) and standard haematocrit (0.45). This rheological advantage may explain the beneficial effect of alpha-thalassaemia 2 on haematological parameters and clinical events in homozygous sickle cell disease.

Type

Journal article

Journal

Br J Haematol

Publication Date

1983

Volume

55

Pages

479 - 486

Keywords

Adolescent Adult Aged Anemia, Sickle Cell/*blood Blood Viscosity Child Erythrocyte Count Erythrocyte Indices Erythrocytes/physiology Filtration Hematocrit Hemoglobin SC Disease/*blood/complications Homozygote Human Male Middle Age Pressure Rheology Thalassemia/*blood/complications Time Factors