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Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease spanning from simple benign steatosis to steatohepatitis with fibrosis and scarring that can eventually lead to cirrhosis. Its prevalence is rising rapidly and is developing into the leading indication for liver transplantation worldwide. Abnormalities in endocrine axes have been associated with NALFD, including hypogonadism, hypothyroidism, GH deficiency and hypercortisolaemia. In some instances, correction of the endocrine defects has been shown to have a beneficial impact. While in patients with type 2 diabetes the association with NAFLD is well established and recognised, there is a more limited appreciation of the condition among common endocrine diseases presenting with hormonal excess or deficiency. In this review, we examine the published data that have suggested a mechanistic link between endocrine abnormalities and NAFLD and summarise the clinical data endorsing these observations.

Original publication

DOI

10.1530/EJE-13-0296

Type

Journal article

Journal

Eur J Endocrinol

Publication Date

08/2013

Volume

169

Pages

R27 - R37

Keywords

Cushing Syndrome, Dwarfism, Pituitary, Fatty Liver, Humans, Hypogonadism, Hypothyroidism, Non-alcoholic Fatty Liver Disease