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The four-vessel occlusion (4-VO) method of global forebrain cerebral ischemia mimics the human clinical condition of cardiac arrest. It results in selective neuronal damage and is a useful experimental system to dissect underlying mechanisms behind ischemic phenomena such as the differential susceptibility of CA1 compared to the CA3 region of the hippocampus. It also provides a "proof-of-principle" system for testing out potential agents for neuroprotection.

Original publication

DOI

10.1007/978-1-4939-0320-7_10

Type

Journal article

Journal

Methods Mol Biol

Publication Date

2014

Volume

1135

Pages

111 - 120

Keywords

Animals, Brain Ischemia, Disease Models, Animal, Heart Arrest, Male, Rats, Rats, Wistar