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The isolated, buffer-perfused ferret heart is a new model for the study of cardiac physiology and metabolism. Compared to the more commonly used isolated heart preparation, the rat heart, the ferret has a lower rate-pressure product due to lower heart rate, a remarkably low coronary flow and almost complete oxygen extraction. The ferret heart remains in stable haemodynamic and metabolic conditions for a longer period of time than the rat heart. ATP contents of the two species are similar, but creatine phosphate content is higher in the ferret while NAD content is much lower.

Original publication

DOI

10.1258/002367791780809995

Type

Journal article

Journal

Lab Anim

Publication Date

10/1991

Volume

25

Pages

348 - 353

Keywords

Adenosine Triphosphate, Animals, Buffers, Ferrets, Heart, Heart Rate, In Vitro Techniques, Male, Models, Biological, Oxygen Consumption, Perfusion, Phosphocreatine