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The large literature on family-based tests of association and/or linkage is reviewed, concentrating on the underlying principles and on recent methodological developments. We explain the distinction between testing for association and testing for linkage, and give our views on the circumstances in which each is the appropriate null hypothesis.

Original publication

DOI

10.1017/S0003480001008818

Type

Journal article

Journal

Ann Hum Genet

Publication Date

09/2001

Volume

65

Pages

407 - 419

Keywords

Alleles, Family, Genetic Linkage, Genetic Markers, Genetics, Medical, Genetics, Population, Genotype, Humans, Linkage Disequilibrium, Models, Genetic, Models, Statistical, Pedigree, Statistics as Topic