The TERT variant rs2736100 is associated with colorectal cancer risk
Kinnersley B., Migliorini G., Broderick P., Whiffin N., Dobbins SE., Casey G., Hopper J., Sieber O., Lipton L., Kerr DJ., Dunlop MG., Tomlinson IP., Houlston RS.
Background: Polymorphic variation at the 5p15.33 (TERT-CLPTM1L) locus is associated with the risk of many cancers but a relationship with colorectal cancer (CRC) risk has yet to be defined.Methods:We used data from six genome-wide association studies (GWAS) of CRC, linkage disequilibrium mapping and imputation, to examine the relationship between 73 single-nucleotide polymorphisms at 5p15.33 and CRC risk in detail.Results:rs2736100, which localises to intron 2 of TERT, provided the strongest evidence of an association with CRC (P 2.28 × 10 -4 ). The association was also shown in an independent series of 10 047 CRC cases and 6918 controls (P0.02). A meta-analysis of all seven studies (totalling 16 039 cases, 16 430 controls) provided increased evidence of association (P2.49 × 10 5; per allele odds ratio1.07). The association of rs2736100 on CRC risk was shown to be independent of 15 low-penetrance variants previously identified.Conclusion:The rs2736100 association demonstrates an influence of variation at 5p15.33 on CRC risk and further evidence that the 5p15.33 (TERT-CLPTM1L) locus has pleiotropic effects (reflecting generic or lineage-specific effects) on cancer risk. © 2012 Cancer Research UK All rights reserved.