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A recombinant vaccinia has been designed to express amino acids 366-379 of influenza nucleoprotein, previously shown to be the minimal epitope recognized by a class I-restricted cytotoxic T cell clone. Target cells infected with the recombinant vaccinia virus expressing this peptide are recognized by CTL as efficiently as target cells expressing the complete nucleoprotein. The results imply the existence of a peptide transport system that constitutively passes the products of degraded proteins from the cytoplasm into a membrane-bound compartment of the cell.

Type

Journal article

Journal

J Exp Med

Publication Date

01/09/1989

Volume

170

Pages

1051 - 1056

Keywords

Animals, Cytoplasm, Epitopes, Histocompatibility Antigens Class I, Influenza A virus, Mice, Mice, Inbred CBA, Nucleoproteins, Peptide Fragments, RNA-Binding Proteins, T-Lymphocytes, Cytotoxic, Vaccinia virus, Viral Core Proteins, Viral Proteins