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Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.

Type

Journal article

Journal

Haematologica

Publication Date

06/2007

Volume

92

Pages

863 - 864

Keywords

Forkhead Transcription Factors, Gene Expression Regulation, Neoplastic, Gene Rearrangement, Humans, In Situ Hybridization, Fluorescence, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Repressor Proteins