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Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myocardial contractility and apoptosis. At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS.

Original publication

DOI

10.1016/j.cytogfr.2006.04.003

Type

Journal article

Journal

Cytokine Growth Factor Rev

Publication Date

08/2006

Volume

17

Pages

225 - 233

Keywords

Acute Disease, Atherosclerosis, Coronary Disease, Cytokines, Humans, Inflammation Mediators, Myocardial Infarction, Prognosis, Syndrome