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The combined effects of smoking and hypercholesterolemia on the inflammatory process, the thrombosis/fibrinolysis system, and forearm hyperemic response were investigated. It was shown that smokers with hypercholesterolemia (n = 25) had a reduced and delayed forearm hyperemic response compared with healthy smokers (n = 24), patients with hypercholesterolemia (n = 26), and healthy controls (n = 75; p <0.01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system.

Original publication




Journal article


Am J Cardiol

Publication Date





1181 - 1184


Adult, Biomarkers, C-Reactive Protein, Cholesterol, Female, Fibrinolysis, Forearm, Humans, Hypercholesterolemia, Hyperemia, Inflammation Mediators, Interleukin-6, Male, Regional Blood Flow, Risk Factors, Smoking, Statistics as Topic, Thrombosis, Tumor Necrosis Factor-alpha, Vasodilation