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Novel recombinant tetrameric complexes of HLA class I molecules allow the direct visualization of antigen-specific CD8+ T cells using flow cytometry. By facilitating the quantification, isolation and phenotypic analysis of CD8+ T cells, the use of HLA tetramers has extended our understanding of the role of cellular immunity in various disease settings. Recently the technique has also been applied to the study of cutaneous disease and provides insights into mechanisms of dermatopathology.

Type

Journal article

Journal

Clin Exp Dermatol

Publication Date

06/2000

Volume

25

Pages

312 - 316

Keywords

Antigens, CD8, Epitopes, Flow Cytometry, Humans, Magnetics, Melanoma, Skin Neoplasms, T-Lymphocyte Subsets, T-Lymphocytes, Cytotoxic, Vitiligo