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BACKGROUND/OBJECTIVES: Fractional iron absorption (FAFe) from ferrous fumarate (FeFum) and ferrous sulfate (FeSO4) in adults is generally comparable. While FeFum is commonly used to fortify infant foods, FAFe from FeFum in young children and infants may be decreased compared with FeSO4 and this effect has not been assessed in inhibitory vs noninhibitory meals. Previous studies also reported FAFe to be strongly correlated in mother-child pairs. Our objective was to measure FAFe from fortified bread labeled with 58FeSO4 and 57FeFum in mother-child pairs with and without a commonly consumed herbal tea of Combretum micranthum (Tisane Kinkéliba, TK). METHODS: Senegalese mother-child pairs (n = 17) were randomly assigned to receive, in a 2 × 2 factorial design, fortified bread with 58FeSO4 or 57FeFum consumed with TK or water. FAFe was assessed by measuring erythrocyte incorporation of stable iron-isotopes 14 days after administration. RESULTS: In children, relative bioavailability (RBV) from FeFum was 51 and 64% compared with FeSO4 when served with TK or water (both, P 

Original publication

DOI

10.1038/s41430-020-0601-z

Type

Journal article

Journal

Eur J Clin Nutr

Publication Date

08/2020

Volume

74

Pages

1221 - 1228

Keywords

Adult, Biological Availability, Bread, Child, Child, Preschool, Female, Ferrous Compounds, Food, Fortified, Humans, Infant, Intestinal Absorption, Iron, Iron, Dietary, Mother-Child Relations, Polyphenols, Tea, Triticum