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Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensitivity of the amide proton exchange rate to changes in pH within the physiological range. Recent studies have demonstrated the possibility of using APT-MRI to detect acidosis of the ischemic penumbra, enabling the assessment of stroke severity and risk of progression, monitoring of treatment progress, and prognostication of clinical outcome. This paper reviews current APT imaging methods actively used in ischemic stroke research and explores the clinical aspects of ischemic stroke and future applications for these methods.

Original publication

DOI

10.1002/nbm.4734

Type

Journal article

Journal

NMR Biomed

Publication Date

06/2023

Volume

36

Keywords

APT, CEST, ischemic penumbra, pH imaging, stroke, Animals, Humans, Protons, Amides, Stroke, Magnetic Resonance Imaging, Ischemic Stroke, Acidosis