Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Remote distal enhancers may be located tens or thousands of kilobases away from their promoters. How they control gene expression is still poorly understood. Here, we analyze the influence of a remote enhancer on the balance between repression (Polycomb-PcG) and activation (Trithorax-TrxG) of a developmentally regulated gene associated with a CpG island. We reveal its essential, nonredundant role in clearing the PcG complex and H3K27me3 from the CpG island. In the absence of the enhancer, the H3K27me3 demethylase (JMJD3) is not recruited to the CpG island. We propose a new role of long-range regulatory elements in removing repressive PcG complexes.

Original publication

DOI

10.1101/gad.16985411

Type

Journal article

Journal

Genes Dev

Publication Date

01/08/2011

Volume

25

Pages

1583 - 1588

Keywords

Animals, Cell Line, Cells, Cultured, Chromatin, Chromatin Immunoprecipitation, CpG Islands, Enhancer Elements, Genetic, Erythropoiesis, Gene Expression Regulation, Humans, Polycomb-Group Proteins, Protein Binding, Protein Methyltransferases, Repressor Proteins