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Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.

Type

Journal article

Journal

J Virol

Publication Date

01/1999

Volume

73

Pages

797 - 800

Keywords

ADP-ribosyl Cyclase, Acquired Immunodeficiency Syndrome, Anti-HIV Agents, Antigens, CD, Antigens, CD38, Antigens, Differentiation, Drug Therapy, Combination, HIV-1, Humans, Membrane Glycoproteins, NAD+ Nucleosidase, T-Lymphocytes, Cytotoxic