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We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

Original publication

DOI

10.2807/1560-7917.es.2019.24.38.1900557

Type

Journal article

Journal

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Publication Date

09/2019

Volume

24

Addresses

National Infection Service, Public Health England, London, United Kingdom.

Keywords

Humans, Chlamydia trachomatis, Chlamydia Infections, False Positive Reactions, Mass Screening, Prevalence, Nucleic Acid Amplification Techniques, Adult, England, Female, Male, Genetic Variation, Young Adult