Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019.
Roberts DJ., Davis GS., Cole MJ., Naik D., Maru H., Woodford N., Muir P., Horner P., Simms I., Thickett G., Crook P., Foster K., Andrews N., Saunders J., Saunders J., Fifer H., Folkard K., Gill ON., On Behalf Of The Incident Management Team None.
We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.