Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Patients with clonal myeloid disorders, especially myelodysplastic syndromes (MDS), may acquire alpha-thalassaemia. To estimate the prevalence of this erythrocyte phenotype, we examined brilliant cresyl blue-stained blood smears from 201 patients with neoplastic myeloid disorders and 282 controls (195 non-clonal anaemia, 62 with medical illnesses without anaemia and 25 healthy persons). Haemoglobin H inclusions were detected in 8/100 patients with MDS (8%) and 2/81 (2.5%) patients with myeloproliferative disorders, but in none of the acute leukaemia patients or controls. We conclude that the emergence of thalassaemic clones may be relatively common in the disordered marrow milieu of MDS.

Original publication

DOI

10.1111/j.1365-2141.2007.06831.x

Type

Journal article

Journal

Br J Haematol

Publication Date

11/2007

Volume

139

Pages

439 - 442

Keywords

Acute Disease, Aged, Erythrocyte Indices, Erythrocytes, Female, Hemoglobin H, Humans, Leukemia, Myeloid, Male, Middle Aged, Myelodysplastic Syndromes, Myeloproliferative Disorders, Prospective Studies, alpha-Thalassemia