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A chemotherapeutic regimen including cisplatin was administered to a man with extragonadal seminoma and cisplatin-induced acute renal failure. Three doses of cisplatin (30, 50, and 100 mg/m2) were given in conjunction with hemodialysis. Pharmacokinetic data for free and total plasma platinum were obtained. The patient also received one dose of carboplatin and a course of radiation therapy. Complete remission was achieved, and useful renal function returned. Cisplatin can be used successfully during acute renal failure.

Original publication

DOI

10.1002/1097-0142(19911015)68:8<1720::aid-cncr2820680812>3.0.co;2-a

Type

Journal article

Journal

Cancer

Publication Date

15/10/1991

Volume

68

Pages

1720 - 1723

Keywords

Acute Kidney Injury, Adult, Antineoplastic Combined Chemotherapy Protocols, Carboplatin, Cisplatin, Dysgerminoma, Humans, Male, Remission Induction, Renal Dialysis, Retroperitoneal Neoplasms