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Twenty four patients with clinical, radiological and biochemical evidence of acromegaly were investigated by a number of independent neurophysiological tests. Two-thirds of the patients showed evidence of generalised peripheral nerve dysfunction. A significant correlation was found between total exchangeable body sodium, an indicator of disease activity, and the severity of the neuropathy. The generalised peripheral nerve abnormality was found to occur independently of the associated carbohydrate intolerance human growth hormone levels and other endocrinological dysfunction in this disorder.

Original publication




Journal article


J Neurol Neurosurg Psychiatry

Publication Date





886 - 894


Acromegaly, Adult, Aged, Carpal Tunnel Syndrome, Female, Hot Temperature, Humans, Male, Middle Aged, Motor Neurons, Neural Conduction, Peripheral Nervous System Diseases, Reaction Time, Sensory Thresholds, Vibration