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The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression.

Original publication

DOI

10.3390/biology8040079

Type

Journal article

Journal

Biology (Basel)

Publication Date

19/10/2019

Volume

8

Keywords

REV-ERBα, biological rhythms, circadian clock, cryptochrome, energy metabolism, liver