Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Family-based studies to map susceptibility genes through linkage disequilibrium have been successful in early-onset diseases where parental-proband trios are readily collected, but are believed to be unworkable for late-onset diseases such as coronary artery disease (CAD). PROCARDIS is a European multicentre study that was designed to identify susceptibility genes for CAD. We have tested the transmission of a putatively functional allele, lymphotoxin-alpha N26 (804A), in more than 400 PROCARDIS trio families. The present study demonstrates association of this allele with CAD in white Europeans, a different ethnic group with a heavier CAD burden than the Japanese in which the association was initially identified, which suggests a broad relevance to CAD susceptibility. The practicalities of implementing a trio-family design for late-onset diseases are discussed.

Original publication

DOI

10.1038/sj.ejhg.5201244

Type

Journal article

Journal

Eur J Hum Genet

Publication Date

09/2004

Volume

12

Pages

770 - 774

Keywords

Alleles, Coronary Artery Disease, DNA Primers, European Continental Ancestry Group, Family, Genetic Predisposition to Disease, Genotype, Humans, Likelihood Functions, Linkage Disequilibrium, Lymphotoxin-alpha, Mass Spectrometry, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Research Design