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The venorelaxant effect of atrial natriuretic factor in man was studied using the dorsal hand vein technique. Infusion of met-ANF to preconstricted veins at doses up to 240 ng min-1 in 11 healthy male subjects caused only minimal venorelaxation. Atrial natriuretic factor is unlikely to have a significant venorelaxant effect at physiological doses in man.

Original publication

DOI

10.1111/j.1365-2125.1988.tb05322.x

Type

Journal article

Journal

Br J Clin Pharmacol

Publication Date

12/1988

Volume

26

Pages

797 - 799

Keywords

Adolescent, Adult, Aged, Atrial Natriuretic Factor, Blood Pressure, Female, Hemodynamics, Humans, Male, Middle Aged, Phenylephrine, Pulse, Vasodilation