A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
Sung YJ., de Las Fuentes L., Winkler TW., Chasman DI., Bentley AR., Kraja AT., Ntalla I., Warren HR., Guo X., Schwander K., Manning AK., Brown MR., Aschard H., Feitosa MF., Franceschini N., Lu Y., Cheng C-Y., Sim X., Vojinovic D., Marten J., Musani SK., Kilpeläinen TO., Richard MA., Aslibekyan S., Bartz TM., Dorajoo R., Li C., Liu Y., Rankinen T., Smith AV., Tajuddin SM., Tayo BO., Zhao W., Zhou Y., Matoba N., Sofer T., Alver M., Amini M., Boissel M., Chai JF., Chen X., Divers J., Gandin I., Gao C., Giulianini F., Goel A., Harris SE., Hartwig FP., He M., Horimoto ARVR., Hsu F-C., Jackson AU., Kammerer CM., Kasturiratne A., Komulainen P., Kühnel B., Leander K., Lee W-J., Lin K-H., Luan J., Lyytikäinen L-P., McKenzie CA., Nelson CP., Noordam R., Scott RA., Sheu WHH., Stančáková A., Takeuchi F., van der Most PJ., Varga TV., Waken RJ., Wang H., Wang Y., Ware EB., Weiss S., Wen W., Yanek LR., Zhang W., Zhao JH., Afaq S., Alfred T., Amin N., Arking DE., Aung T., Barr RG., Bielak LF., Boerwinkle E., Bottinger EP., Braund PS., Brody JA., Broeckel U., Cade B., Campbell A., Canouil M., Chakravarti A., Cocca M., Collins FS., Connell JM., de Mutsert R., de Silva HJ., Dörr M., Duan Q., Eaton CB., Ehret G., Evangelou E., Faul JD., Forouhi NG., Franco OH., Friedlander Y., Gao H., Gigante B., Gu CC., Gupta P., Hagenaars SP., Harris TB., He J., Heikkinen S., Heng C-K., Hofman A., Howard BV., Hunt SC., Irvin MR., Jia Y., Katsuya T., Kaufman J., Kerrison ND., Khor CC., Koh W-P., Koistinen HA., Kooperberg CB., Krieger JE., Kubo M., Kutalik Z., Kuusisto J., Lakka TA., Langefeld CD., Langenberg C., Launer LJ., Lee JH., Lehne B., Levy D., Lewis CE., Li Y., Lifelines Cohort Study None., Lim SH., Liu C-T., Liu J., Liu J., Liu Y., Loh M., Lohman KK., Louie T., Mägi R., Matsuda K., Meitinger T., Metspalu A., Milani L., Momozawa Y., Mosley TH., Nalls MA., Nasri U., O'Connell JR., Ogunniyi A., Palmas WR., Palmer ND., Pankow JS., Pedersen NL., Peters A., Peyser PA., Polasek O., Porteous D., Raitakari OT., Renström F., Rice TK., Ridker PM., Robino A., Robinson JG., Rose LM., Rudan I., Sabanayagam C., Salako BL., Sandow K., Schmidt CO., Schreiner PJ., Scott WR., Sever P., Sims M., Sitlani CM., Smith BH., Smith JA., Snieder H., Starr JM., Strauch K., Tang H., Taylor KD., Teo YY., Tham YC., Uitterlinden AG., Waldenberger M., Wang L., Wang YX., Wei WB., Wilson G., Wojczynski MK., Xiang Y-B., Yao J., Yuan J-M., Zonderman AB., Becker DM., Boehnke M., Bowden DW., Chambers JC., Chen Y-DI., Weir DR., de Faire U., Deary IJ., Esko T., Farrall M., Forrester T., Freedman BI., Froguel P., Gasparini P., Gieger C., Horta BL., Hung Y-J., Jonas JB., Kato N., Kooner JS., Laakso M., Lehtimäki T., Liang K-W., Magnusson PKE., Oldehinkel AJ., Pereira AC., Perls T., Rauramaa R., Redline S., Rettig R., Samani NJ., Scott J., Shu X-O., van der Harst P., Wagenknecht LE., Wareham NJ., Watkins H., Wickremasinghe AR., Wu T., Kamatani Y., Laurie CC., Bouchard C., Cooper RS., Evans MK., Gudnason V., Hixson J., Kardia SLR., Kritchevsky SB., Psaty BM., van Dam RM., Arnett DK., Mook-Kanamori DO., Fornage M., Fox ER., Hayward C., van Duijn CM., Tai ES., Wong TY., Loos RJF., Reiner AP., Rotimi CN., Bierut LJ., Zhu X., Cupples LA., Province MA., Rotter JI., Franks PW., Rice K., Elliott P., Caulfield MJ., Gauderman WJ., Munroe PB., Rao DC., Morrison AC.
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P