Fostering Confidence: Evaluating the Reproducibility and Reliability of Bingham-NODDI Model Measures on Different 3.0 T MRI Scanners

Motivation: The NODDI model has been proven to be a powerful tool, however it struggles to depict complex brain neurite structures. Goal(s): The Bingham-NODDI model offers a more detailed approach for capturing pathological-related brain changes, although its validation is still ongoing. This study aims to make progress in this direction. Approach: To assess the Bingham-NODDI model's reliability across different MRI scanner systems, this study uses a consistent acquisition protocol, fostering the model's robustness. Results: The outcomes confirm Bingham-NODDI model’s reliability, promising potential clinical applications. By enhancing generalizability and validation, this research clears the path for improved diagnostic and research tools in neuroscience. Impact: The Bingham-NODDI model offers valuable insights into brain microstructure changes. Its integration into clinical practice alongside medical teams and neuroscientists is highly promising. This multi-center study advances this goal by assessing model stability, fostering future collaborations between scientistis and clinicians.