Expression profiling of persistent polyclonal B-cell lymphocytosis suggests constitutive expression of the AP-1 transcription complex and downregulation of Fas-apoptotic and TGFbeta signalling pathways.

Lawrie CH.; Shilling R.; Troussard X.; Cattan H.; Mossafa H.; Pezzella F.; Boultwood J.; Wainscoat JS.; Hatton CSR.

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Expression profiling of persistent polyclonal B-cell lymphocytosis suggests constitutive expression of the AP-1 transcription complex and downregulation of Fas-apoptotic and TGFbeta signalling pathways.

Lawrie CH., Shilling R., Troussard X., Cattan H., Mossafa H., Pezzella F., Boultwood J., Wainscoat JS., Hatton CSR.

Original publication

DOI

10.1038/leu.2008.223

Type

Journal article

Journal

Leukemia

Publication Date

03/2009

Volume

Pages

581 - 583

Keywords

Adult, Apoptosis, Apoptosis Regulatory Proteins, B-Lymphocytes, Basic-Leucine Zipper Transcription Factors, Diagnosis, Differential, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Inhibitor of Differentiation Protein 2, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocytosis, Male, Middle Aged, NAV1.3 Voltage-Gated Sodium Channel, Oligonucleotide Array Sequence Analysis, Oncogene Proteins v-fos, Protein Kinase Inhibitors, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-jun, Receptors, Purinergic P2, Receptors, Purinergic P2Y, Signal Transduction, Smad4 Protein, Smoking, Sodium Channels, Transcription Factor AP-1, Transforming Growth Factor beta, fas Receptor