man genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.
Bueno C., Torres-Ruiz R., Velasco-Hernandez T., Molina O., Petazzi P., Martinez A., Rodriguez V., Vinyoles M., Cantilena S., Williams O., Vega-Garcia N., Rodriguez-Perales S., Segovia JC., Quintana-Bustamante O., Roy A., Meyer C., Marschalek R., Smith AL., Milne TA., Fraga MF., Tejedor JR., Menéndez P.
Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.