A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function.
Broichhagen J., Frank JA., Johnston NR., Mitchell RK., Šmid K., Marchetti P., Bugliani M., Rutter GA., Trauner D., Hodson DJ.
Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.