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AIMS: Progressive left ventricular (LV) remodelling with cardiac myocyte hypertrophy, myocardial fibrosis, and endothelial dysfunction plays a key role in the onset and progression of heart failure with preserved ejection fraction. The Beta3-LVH trial will test the hypothesis that the β3 adrenergic receptor agonist mirabegron will improve LV hypertrophy and diastolic function in patients with hypertensive structural heart disease at high risk for developing heart failure with preserved ejection fraction. METHODS AND RESULTS: Beta3-LVH is a randomized, placebo-controlled, double-blind, two-armed, multicentre, European, parallel group study. A total of 296 patients will be randomly assigned to receive either mirabegron 50 mg daily or placebo over 12 months. The main inclusion criterion is the presence of LV hypertrophy, that is, increased LV mass index (LVMi) or increased wall thickening by echocardiography. The co-primary endpoints are a change in LVMi by cardiac magnetic resonance imaging and a change in LV diastolic function (assessed by the E/e' ratio). Secondary endpoints include mirabegron's effects on cardiac fibrosis, left atrial volume index, maximal exercise capacity, and laboratory markers. Two substudies will evaluate mirabegron's effect on endothelial function by pulse amplitude tonometry and brown fat activity by positron emission tomography using 17F-fluorodeoxyglucose. Morbidity and mortality as well as safety aspects will also be assessed. CONCLUSIONS: Beta3-LVH is the first large-scale clinical trial to evaluate the effects of mirabegron on LVMi and diastolic function in patients with LVH. Beta3-LVH will provide important information about the clinical course of this condition and may have significant impact on treatment strategies and future trials in these patients.

Original publication

DOI

10.1002/ehf2.12306

Type

Journal article

Journal

ESC Heart Fail

Publication Date

10/2018

Volume

5

Pages

830 - 841

Keywords

Heart failure with preserved ejection fraction, Hypertensive structural heart disease, Mirabegron, β3 adrenergic receptor, Acetanilides, Adolescent, Adrenergic beta-3 Receptor Agonists, Adult, Aged, Aged, 80 and over, Diastole, Disease Progression, Double-Blind Method, Echocardiography, Female, Follow-Up Studies, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Prospective Studies, Stroke Volume, Thiazoles, Treatment Outcome, Ventricular Function, Left, Ventricular Remodeling, Young Adult