Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study.
Hill MD., Kent DM., Hinchey J., Rowley H., Buchan AM., Wechsler LR., Higashida RT., Fischbein NJ., Dillon WP., Gent M., Firszt CM., Schulz GA., Furlan AJ., PROACT-2 Investigators .
BACKGROUND AND PURPOSE: Sex influences outcome after intravenous thrombolysis. In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set. METHODS: Data were from the Pro-Urokinase for Acute Cerebral Thromboembolism-2 (PROACT-2) trial. Baseline factors were compared by sex. The primary outcome was an assessment of a sex-by-treatment interaction term within a logistic regression model, using a modified Rankin Scale score