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Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.

Type

Journal article

Journal

Science

Publication Date

20/05/1988

Volume

240

Pages

1003 - 1009

Keywords

Amino Acid Sequence, Arthritis, Rheumatoid, Autoantibodies, Autoimmune Diseases, Diabetes Mellitus, Type 1, HLA-D Antigens, Humans, Major Histocompatibility Complex, Molecular Sequence Data, Pemphigus